I haven't had a period in three months, and I have had a problem with irregular periods as long as I can remember along with hot flashes. I keep aksing my doctors if I am going through the change. I am on Prozac 40 mg a day, take clonopin when needed for anxiety, midring for migraines, and my bones ache so bad sometimes I take darvocet or vicadin when needed. I don't think the anti depressant has anything to do with my missed periods as much as my stress levels and depression do. Especially since I have had this problem since my teens. For a while I was regular, then I get irregular....can't seem to win, So I am going to get back on Loestrin FE/120 to regulate me for a while.